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- Title
Special regulatory T-cell review: T-cell dependent suppression revisited.
- Authors
Basten, Antony; de St Groth, Barbara Fazekas
- Abstract
The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system.
- Subjects
T cells; IMMUNE response; IMMUNOSUPPRESSION; SUPPRESSOR cells; IMMUNE system; IMMUNOLOGY
- Publication
Immunology, 2008, Vol 123, Issue 1, p33
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1111/j.1365-2567.2007.02772.x