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- Title
Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis.
- Authors
Saito, Hiroko; Morikawa, Hiroshi; Howie, Karen; Crawford, Lynn; Baatjes, Adrian J.; Denburg, Elisha; Cyr, Michael M.; Denburg, Judah A.
- Abstract
The cysteinyl leukotrienes (cysLTs) are potent lipid mediators in allergic disease, acting through a receptor (cysLT1-R) which can be targeted in rhinitis and asthma. We investigated the effects of cysLT1-R antagonism in experimental allergic rhinitis, focusing on bone marrow eosinophil progenitor responses. BALB/c mice were sensitized, then given daily intranasal ovalbumin for 2 weeks, with montelukast sodium (5 mg/kg or 2·5 mg/kg) or placebo by gavage. Bone marrow eosinophil/basophil colonies were enumerated, and colony cells were morphologically assessed as indices of eosinophil differentiation and maturation. Montelukast treatment resulted in a significant decrease of eosinophils in the nasal mucosa, and in either bone marrow interleukin (IL)-5-, but not IL-3-, or granulocyte-macrophage colony-stimulating factor-responsive eosinophil/basophil colony-forming units, and IL-5-stimulated eosinophil maturation. These results indicate that cysLT1-R antagonismin vivolimits both IL-5-responsive eosinophilopoiesis, acting at several stages of eosinophil differentiation and maturation. The anti-allergic effects of cysLT1-R antagonists are consistent with the concept that cysLTs and IL-5 act together in the recruitment of eosinophils and eosinophil progenitors from the marrow during upper airway allergic inflammation.
- Subjects
ALLERGIC rhinitis; EOSINOPHILS; HEMATOPOIESIS; INTERLEUKINS; MACROPHAGES; IMMUNOLOGY
- Publication
Immunology, 2004, Vol 113, Issue 2, p246
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1111/j.1365-2567.2004.01944.x