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- Title
The definition of tuberculosis infection based on the spectrum of tuberculosis disease.
- Authors
Migliori, Giovanni Battista; Ong, Catherine W. M.; Petrone, Linda; D'Ambrosio, Lia; Centis, Rosella; Goletti, Delia
- Abstract
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define "a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-γ release assay (IGRA) without clinically active TB". Recent evidence indicates that the spectrum from TB infection to TB disease is much more complex, including a "continuum" of situations didactically reported as uninfected individual, TB infection, incipient TB, subclinical TB without signs/symptoms, subclinical TB with unrecognised signs/symptoms, and TB disease with signs/symptoms. Recent evidence suggests that subclinical TB is responsible for important M. tuberculosis transmission. This review describes the different stages described above and their relationships. It also summarises the new developments in prevention, diagnosis and treatment of TB infection as well as their public health and policy implications.
- Subjects
TUBERCULOSIS diagnosis; TUBERCULOSIS prevention; TUBERCULOSIS treatment; HEALTH policy; PUBLIC health; INFECTION; TUBERCULOSIS; SYMPTOMS
- Publication
Breathe, 2021, Vol 17, Issue 3, p1
- ISSN
1810-6838
- Publication type
Article
- DOI
10.1183/20734735.0079-2021