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- Title
Neural Circuitry Underlying Rule Use in Humans and Nonhuman Primates.
- Authors
Bunge, Silvia A.; Wallis, Jonathan D.; Parker, Amanda; Brass, Marcel; Crone, Eveline A.; Hoshi, Eiji; Sakai, Katsuyuki
- Abstract
The article presents a study which examines the varying levels of complexity represented in the brain of human and nonhuman primates, ranging from simple stimulus-reward association to conditional rules to higher-level task rules. The ability to learn that a given action is associated with a reward, and to flexibly update this association as needed, relies on orbitofrontal cortex. In the monkey, bilateral damage to orbitofrontal cortex, or a disconnection between the amygdala and the orbitofrontal cortex disrupts the ability to select a response on the basis of predicted reward outcomes.
- Subjects
BRAIN function localization; BRAIN research; PRIMATES; HUMAN beings; MONKEYS; REWARD (Psychology)
- Publication
Journal of Neuroscience, 2005, Vol 25, Issue 45, p10347
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2937-05.2005