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- Title
Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy.
- Authors
Ye-Ping Ma; Yue Yang; Shi-Min Jiang; Lin Liu; Zheng Zhang; Yi-Ning Wang; Gu-Ming Zou; Wen-Ge Li; Ma, Ye-Ping; Yang, Yue; Jiang, Shi-Min; Liu, Lin; Zhang, Zheng; Wang, Yi-Ning; Zou, Gu-Ming; Li, Wen-Ge
- Abstract
<bold>Introduction: </bold>The aims of this study were to assess the renal expression of angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and MAS receptor in human type 2 diabetic nephropathy (DN).<bold>Materials and Methods: </bold>In total, 115 patients diagnosed with DN by renal biopsy were enrolled in this study. The protein expression levels of the AT1R, AT2R, and MAS receptors were assessed by immunohistochemistry.<bold>Results: </bold>The protein expression levels of AT1R, AT2R, and MAS receptor in the renal biopsy tissue were correlated with the pathologic classification of DN. Tubulointerstitial AT1R expression in patients of class IIb was significantly stronger than control samples (p < 0.05). Expression of AT2R and MAS receptors were highest with class IIb DN patients. When DN patients were treated with AT1R blocker (ARB), the expression of AT1R was downregulated (p < 0.05), and the MAS receptor was upregulated in tubular interstitial (p < 0.05).<bold>Conclusions: </bold>Our results directly observed that renal expression levels of AT1R increase during the early stages of DN, ARB reducing AT1R while increasing MAS receptor. Therefore, ARB should be used as soon as possible in patients with DN.
- Subjects
PROTEINS; KIDNEYS; BIOPSY; DIABETIC neuropathies; CELL receptors; KIDNEY tubules; ANGIOTENSIN receptors; ANGIOTENSIN II
- Publication
Journal of the Renin-Angiotensin-Aldosterone System, 2020, Vol 21, Issue 2, p1
- ISSN
1470-3203
- Publication type
journal article
- DOI
10.1177/1470320320919607