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- Title
What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia?
- Authors
Altamura, C.; Squitti, R.; Pasqualetti, P.; Tibuzzi, F.; Silvestrini, M.; Ventriglia, M. C.; Cassetta, E.; Rossini, P. M.; Vernieri, F.
- Abstract
Evidence suggests the important role of vascular factors both in vascular dementia (VaD) and Alzheimer disease (AD) pathogenesis. However, the relationship between apolipoprotein E (APOE) polymorphism and markers of atherosclerosis is still controversial. The aim of the study was to investigate the interplay between APOE polymorphisms and atherosclerosis in patients with AD and VaD. In this cross-sectional study, 101 demented (68 AD and 33 VaD) patients underwent APOE genotyping and neck vessel ultrasound to evaluate carotid artery disease [intima-media thickness (IMT) and plaques]. Patients with AD carrying ℇ4 allele presented increased IMT values with respect to non- ℇ4 carriers and VaD patients, whereas no relation was found between APOE polymorphisms and the presence or grade of carotid plaques both in AD and VaD patients. The ℇ4 APOE allele may promote intima-media thickening, interacting with other factors contributing to AD development.
- Subjects
CARDIOVASCULAR system; VASCULAR dementia; ATHEROSCLEROSIS; APOLIPOPROTEINS; ALZHEIMER'S disease; MEDICAL imaging systems
- Publication
European Journal of Neurology, 2007, Vol 14, Issue 6, p679
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/j.1468-1331.2007.01714.x