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- Title
18F-fluoro-2-deoxy-d-glucose (FDG) uptake. What are we looking at?
- Authors
Sambuceti, Gianmario; Cossu, Vanessa; Bauckneht, Matteo; Morbelli, Silvia; Orengo, AnnaMaria; Carta, Sonia; Ravera, Silvia; Bruno, Silvia; Marini, Cecilia
- Abstract
Again, ex vivo simultaneous measurement of cardiac tracer uptake and glucose consumption documented a marked increase in LC that was not related to any change in its theoretical determinant, thus confirming the elusive link between FDG retention and glucose consumption [[25]-[27]]. Studying the response of glucose consumption and FDG uptake to the prolonged treatment with high doses of metformin in the normal mouse brain, Cossu et al. documented a profound decrease in FDG uptake [[46]]. Current model of FDG uptake The current interpretation of FDG imaging derives from the tight and local connection between glucose consumption and SP 14 sp C-2-deoxyglucose (2DG) uptake, described in the seminal work by Sokoloff et al. [[2]] in the brain of albino rats. The ER as escape gate and accumulation site of FDG radioactivity Altogether, experimental findings and theoretical considerations indicate that FDG accumulation might at least partially reflect the activation degree of a still undefined glucose processing pathway that should be related, but not identical, to the PPP and located within the ER.
- Subjects
GLUCOSE-6-phosphate dehydrogenase; GLUCOSE transporters; GLYCOLYSIS; NUCLEAR magnetic resonance spectroscopy
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2021, Vol 48, Issue 5, p1278
- ISSN
1619-7070
- Publication type
Editorial
- DOI
10.1007/s00259-021-05368-2