We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Long-Term Low Intensity Physical Exercise Attenuates Heart Failure Development in Aging Spontaneously Hypertensive Rats.
- Authors
Pagan, Luana U.; Damatto, Ricardo L.; Cezar, Marcelo D.M.; Lima, aline R.R.; Bonomo, Camila; Campos, Dijon H.S.; Gomes, Mariana J.; Martinez, Paula F.; Oliveira Jr, Silvio a.; Gimenes, Rodrigo; Rosa, Camila M.; Guizoni, Daniele M.; Moukbel, Yasmin C.; Cicogna, antonio C.; Okoshi, Marina P.; Okoshi, Katashi
- Abstract
Background: Physical exercise is a strategy to control hypertension and attenuate pressure overload-induced cardiac remodeling. The influence of exercise on cardiac remodeling during uncontrolled hypertension is not established. We evaluated the effects of a long-term low intensity aerobic exercise protocol on heart failure (HF) development and cardiac remodeling in aging spontaneously hypertensive rats (SHR). Methods: Sixteen month old SHR (n=50) and normotensive Wistar-Kyoto (WKY, n=35) rats were divided into sedentary (SED) and exercised (EX) groups. Rats exercised in treadmill at 12 m/min, 30 min/day, 5 days/week, for four months. The frequency of HF features was evaluated at euthanasia. Statistical analyses: ANOVA and Tukey or Mann-Whitney, and Goodman test. Results: Despite slightly higher systolic blood pressure, SHR-EX had better functional capacity and lower HF frequency than SHR-SED. Echocardiography and tissue Doppler imaging showed no differences between SHR groups. In SHR-EX, however, left ventricular (LV) systolic diameter, larger in SHR-SED than WKY-SED, and endocardial fractional shortening, lower in SHR-SED than WKY-SED, had values between those in WKY-EX and SHR-SED not differing from either group. Myocardial function, assessed in LV papillary muscles, showed improvement in SHR-EX over SHR-SED and WKY-EX. LV myocardial collagen fraction and type I and III collagen gene expression were increased in SHR groups. Myocardial hydroxyproline concentration was lower in SHR-EX than SHR-SED. Lysyl oxidase gene expression was higher in SHR-SED than WKY-SED. Conclusion: Exercise improves functional capacity and reduces decompensated HF in aging SHR independent of elevated arterial pressure. Improvement in functional status is combined with attenuation of LV and myocardial dysfunction and fibrosis. © 2015 S. Karger AG, Basel
- Subjects
HEART failure; EXERCISE physiology; CELLULAR aging; HYPERTENSION; AEROBIC exercises; SYSTOLIC blood pressure
- Publication
Cellular Physiology & Biochemistry (Karger AG), 2015, Vol 36, Issue 1, p61
- ISSN
1015-8987
- Publication type
Article
- DOI
10.1159/000374053