We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Rheological properties of an original pharmaceutical composition of a nanostructured silver system stabilized by arabinogalactan.
- Authors
Romanko, T.; Kostyro, Ya.; Gumennikova, E.; Alekseev, K.; Romanko, V.; Grishchenko, L.; Yes'kova, L.; Ostroukhova, L.; Babkin, V.; Trofimov, B.
- Abstract
Rheological properties of an original pharmaceutical composition of a nanostructured (ultradisperse) silver system stabilized by arabinogalactan were studied by dynamic rheology and compared with the official silver- containing preparation dermazin. Significant differences were observed in the rheological characteristics of the soft dosage forms that affected their adherence to skin, the bioavailability of the active ingredients, and the production technology. It was established that the original pharmaceutical composition of the ultradisperse silver system stabilized by arabinogalactan was a structured liquid with clearly pronounced non-Newtonian flow characteristics that exhibited viscoplastic and thixotropic properties. Its rheological parameters corresponded well to requirements for the technical rheological optimum for extrusion of hydrophilic gels.
- Subjects
SILVER nanoparticles; ARABINOGALACTAN; RHEOLOGY; SILVER sulfadiazine; DOSAGE forms of drugs; BIOAVAILABILITY; NON-Newtonian flow (Fluid dynamics)
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 2, p99
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0904-7