We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease.
- Authors
Foerde, Karin; Figner, Bernd; Doll, Bradley B.; Woyke, Isabel C.; Braun, Erin Kendall; Weber, Elke U.; Shohamy, Daphna
- Abstract
Choosing between smaller prompt rewards and larger later rewards is a common choice problem, and studies widely agree that frontostriatal circuits heavily innervated by dopamine are centrally involved. Understanding how dopamine modulates intertemporal choice has important implications for neurobiological models and for understanding the mechanisms underlying maladaptive decision-making. However, the specific role of dopamine in intertemporal decisions is not well understood. Dopamine may play a role in multiple aspects of intertemporal choices-the valuation of choice outcomes and sensitivity to reward delays. To assess the role of dopamine in intertemporal decisions, we tested Parkinson disease patients who suffer from dopamine depletion in the striatum, in either high (on medication, PDON) or low (off medication, PDOFF) dopaminergic states. Compared with both PDOFF and healthy controls, PDON made more farsighted choices and reduced their valuations less as a function of increasing time to reward. Furthermore, reduced discounting in the high dopaminergic state was robust across multiple measures, providing new evidence for dopamine's role in making decisions about the future.
- Subjects
PARKINSON'S disease; DOPAMINE; DECISION making; DRUG utilization; DOPAMINERGIC neurons
- Publication
Journal of Cognitive Neuroscience, 2016, Vol 28, Issue 5, p657
- ISSN
0898-929X
- Publication type
Article
- DOI
10.1162/jocn_a_00929