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- Title
An MRI-Based Semiquantitative Index for the Evaluation of Brain Atrophy and Lesions in Alzheimer's Disease, Mild Cognitive Impairment and Normal Aging.
- Authors
Chen, Wei; Song, Xiaowei; Zhang, Yunting; Darvesh, Sultan; Zhang, Ningnannan; D'Arcy, Ryan C.N.; Black, Sandra; Rockwood, Kenneth
- Abstract
Background: This study investigates how T1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T1- and T2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging. Copyright © 2010 S. Karger AG, Basel
- Subjects
RADIOGRAPHY; AGING; ALZHEIMER'S disease; ANALYSIS of variance; BRAIN; COMPUTER software; MAGNETIC resonance imaging; RESEARCH funding; STATISTICS; DATA analysis; RECEIVER operating characteristic curves; DIAGNOSIS; ATROPHY
- Publication
Dementia & Geriatric Cognitive Disorders, 2010, Vol 30, Issue 2, p121
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000319537