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- Title
CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value.
- Authors
Jie Wu; Lan Li; Siyi Wu; Bin Xu
- Abstract
The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1-8 (previously called chemokine-like factor superfamily 1-8, CKLFSF1-8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1-8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
- Subjects
PROTEINS; APOPTOSIS; TUMOR growth; BIOMARKERS; CELL proliferation
- Publication
Cancer Biology & Medicine, 2020, Vol 17, Issue 3, p528
- ISSN
2095-3941
- Publication type
Article
- DOI
10.20892/j.issn.2095-3941.2020.0032