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- Title
Dehydroepiandrosterone-sulfate concentration in men from a Japanese longevity district.
- Authors
Matsumoto, Masami; Ishizuka, Tatsuo; Kajita, Kazuo; Sugiyama, Chiyo; Morita, Hiroyuki; Uno, Yoshihiro; Ikeda, Takahide; Mori, Ichiro; Matsubara, Kenji; Takeda, Noriyuki; Yamakita, Noriyoshi; Yasuda, Keigo
- Abstract
Background: To clarify the effect of dehydroepiandrosterone (DHEA) on the association of DHEA with longevity in male adults in Japan, we measured DHEA-sulfate (DHEA-S) concentration in male adults from a Japanese longevity district. Methods: We measured serum DHEA-S concentration, fasting plasma glucose (FPG), 2-h plasma glucose after 75 g oral glucose loading (2hrPG), fasting insulin (FIRI) and HbA1c, adiponectin of 34 male adults in Kokufu-cho, one of the highest longevity districts (mean lifespan in males, 80.4 years) and those of 559 male adults in Kasamatsu-cho (mean lifespan, 77.6 years) as control. Results: There was a significant difference of mean age between Kokufu-cho (72 ± 7 years) and Kasamatsu-cho (51 ± 8 years) ( P < 0.0001). FIRI levels in Kasamatsu-cho (7.4 ± 3.3 μU/mL) were significantly higher than in Kokufu-cho (5.3 ± 4.0 μU/mL) ( P < 0.005). The quantative insulin sensitivity check index (QUICKI) was significantly higher and homeostasis model assessment was significantly lower in Kokufu-cho than those in Kasamatsu-cho ( P < 0.001). Serum DHEA-S concentrations of male adults in Kokufu-cho, a longevity district of Japan, were significantly higher than in Kasamatsu-cho as control, if adjusted for age, body mass index and blood glucose ( P < 0.0001). Negative correlation of DHEA-S with age was expectedly found ( P < 0.0001) in a total of 593 male adults. Sixteen male adults in Kasamatsu-cho and 22 male adults in Kokufu-cho aged 68–73 years were selected. DHEA-S concentrations of male adults in Kokufu-cho were significantly higher than in Kasamatsu-cho, if adjusted for body mass index, body fat composition, blood pressure, lipids values, FIRI and FPG ( P < 0.036). Conclusion: DHEA may contribute to longevity in elderly men.
- Subjects
JAPAN; DEHYDROEPIANDROSTERONE; LONGEVITY; HEALTH of older men; COMPARATIVE studies; CONTROL groups
- Publication
Geriatrics & Gerontology International, 2007, Vol 7, Issue 4, p352
- ISSN
1444-1586
- Publication type
Article
- DOI
10.1111/j.1447-0594.2007.00424.x