We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acute kidney injury in 3182 patients admitted with COVID-19: a single-center, retrospective, case–control study.
- Authors
Procaccini, Fabio L; Arroyo, Roberto Alcázar; Ramón, Marta Albalate; Aguilera, Esther Torres; Navarro, Juan Martín; Murua, Pablo Ryan; Cabrera, Melissa Cintra; Díaz, Mayra Ortega; Carretero, Marta Puerta; Ortiz, Patricia de Sequera
- Abstract
Background Acute kidney injury (AKI) may develop in coronavirus disease 2019 (COVID-19) patients and may be associated with a worse outcome. The aim of this study is to describe AKI incidence during the first 45 days of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Spain, its reversibility and the association with mortality. Methods This was an observational retrospective case–control study based on patients hospitalized between 1 March and 15 April 2020 with SARS-CoV-2 infection and AKI. Confirmed AKI cases were compared with stable kidney function patients for baseline characteristics, analytical data, treatment and renal outcome. Patients with end-stage kidney disease were excluded. Results AKI incidence was 17.22% among 3182 admitted COVID-19 patients and acute kidney disease (AKD) incidence was 6.82%. The most frequent causes of AKI were prerenal (68.8%) and sepsis (21.9%). Odds ratio (OR) for AKI was increased in patients with pre-existent hypertension [OR 2.58, 95% confidence interval (CI) 1.71–3.89] and chronic kidney disease (CKD) (OR 2.14, 95% CI 1.33–3.42) and in those with respiratory distress (OR 2.37, 95% CI 1.52–3.70). Low arterial pressure at admission increased the risk for Stage 3 AKI (OR 1.65, 95% CI 1.09–2.50). Baseline kidney function was not recovered in 45.73% of overall AKI cases and in 52.75% of AKI patients with prior CKD. Mortality was 38.5% compared with 13.4% of the overall sample population. AKI increased mortality risk at any time of hospitalization (hazard ratio 1.45, 95% CI 1.09–1.93). Conclusions AKI is frequent in COVID-19 patients and is associated with mortality, independently of acute respiratory distress syndrome. AKD was also frequent and merits adequate follow-up.
- Subjects
SPAIN; ACUTE kidney failure; COVID-19; CHRONIC kidney failure; ADULT respiratory distress syndrome; CASE-control method
- Publication
Clinical Kidney Journal, 2021, Vol 14, Issue 6, p1557
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfab021