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- Title
Increase of circulating γ/δ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease.
- Authors
Giacomelli, R.; Parzanese, I.; Frieri, G.; Passacantando, A.; Pizzuto, F.; Pimpo, T.; Cipriani, P.; Viscido, A.; Caprilli, R.; Tonietti, G.
- Abstract
In order to study the role of γ/δ T cells in the pathogenesis of inflammatory bowel disease (IBD) in humans, we measured the percentage of these cells in the peripheral blood, assessed the ratio of the non-disulphide-linked (δTCS1) type of T cell receptor (TCR) in the total γ/δ T cells, studied the co-expression of γ/δ TCR and accessory molecules CDS and CD 16, and compared these data with both the type and the activity of the disease. Percentage levels and absolute numbers of γ/δ+ T cells were higher in active patients than in controls (P < 005), mainly as a result of an increase of Vδ1+ (δTCS1)T cell subset (P < 0.05). This trend was strongly retained independently of disease activity and clinical picture. An increased percentage of TCRδ1+/CD16+ cells was observed in our patients compared with controls (P < 0.05). In contrast, no difference was observed as far as the TCRδ1+/CD8+ cells were concerned. These results suggest that IBD is associated with an expansion of γ/δ T cells in peripheral blood, which may play a role in the pathogenesis of these disorders.
- Subjects
INFLAMMATORY bowel diseases; INTESTINAL diseases; LYMPHOCYTES; T cell receptors; BLOOD; LEUCOCYTES
- Publication
Clinical & Experimental Immunology, 1994, Vol 98, Issue 1, p83
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/1365-2249.ep15984971