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- Title
Volatile organic compounds as potential biomarkers of irritable bowel syndrome: A systematic review.
- Authors
Zhang, Valencia Ru‐Yan; Ramachandran, Gokula Krishnan; Loo, Evelyn Xiu Ling; Soh, Alex Yu Sen; Yong, Wei Peng; Siah, Kewin Tien Ho
- Abstract
Background: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disease characterized by intermittent abdominal pain with altered bowel habits. Due to the condition's chronicity, patients suffer from poor quality of life, while the healthcare burden continues to grow. There is currently no reliable biomarker for the diagnosis of IBS, and the current approach depends on ruling‐out organic diseases such as inflammatory bowel disease (IBD) and colorectal cancer by markers of inflammation like fecal calprotectin and C‐reactive protein, or invasive procedures like a colonoscopy. Volatile organic compounds (VOCs) are growing in popularity as a biomarker due to its accuracy and ease of use. Purpose: This systematic review of Medline and Cochrane's databases aimed to identify VOCs in the diagnosis of IBS. 57% of the studies proved that VOCs could identify IBS patients from healthy controls with AUC ranging from 0.83 to 0.99. Studies that distinguished IBS from IBD patients had slightly higher AUC of 0.87–0.98. Combining VOC into panels allowed the creation of discriminative algorithms. Though current research is limited by areas of heterogeneity in VOC sampling and small sample sizes, our review shows that VOC analysis has the potential to be a noninvasive point‐of‐care test that differentiates IBS from other organic gastrointestinal diseases.
- Subjects
IRRITABLE colon; VOLATILE organic compounds; INFLAMMATORY bowel diseases; GASTROINTESTINAL diseases; TUMOR markers; C-reactive protein
- Publication
Neurogastroenterology & Motility, 2023, Vol 35, Issue 7, p1
- ISSN
1350-1925
- Publication type
Article
- DOI
10.1111/nmo.14536