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- Title
The VAD chemotherapy regimen plus a G-CSF dose of 10 μg/kg is as effective and less toxic than high-dose cyclophosphamide plus a G-CSF dose of 5 μg/kg for progenitor cell mobilization: results from a monocentric study of 82 patients.
- Authors
Lefrère, F.; Zohar, S.; Ghez, D.; Delarue, R.; Audat, F.; Suarez, F.; Hermine, O.; Damaj, G.; Maillard, N.; Ribeil, J. A.; Azagury, M.; Misbahi, R.; Jondeau, K.; Cavazzana-Calvo, M.; Dal Cortivo, L.; Varet, B.
- Abstract
A study was conducted to compare the efficiency and toxicity of two peripheral blood stem cell (PBSC) mobilization procedures for newly diagnosed patients with multiple myeloma. Patients from group 1 (n=51) were treated by high-dose cyclophosphamide (HD-CY) plus G-CSF (5 μg/kg/day), and the second group (n=31) by VAD regimen plus G-CSF administration (10 μg/kg/day). Successful mobilization, defined by a minimal count of 2.5 × 106 CD34+ cells/kg collected, was achieved in 96 and 90% of patients in groups 1 and 2, respectively (P=0.15). The mean peripheral blood CD34+ cells concentration and the mean CD34+ cells/kg collected were higher in group 2 than in the group 1 (P=0.05). The mean number of leukaphereses necessary to collect a count of 2.5 × 106 CD34+ cells/kg was reduced in group 2 compared to group 1. Adverse events, blood products consumption and time spent in the hospital were significantly greater after HD-CY. In conclusion, VAD plus a G-CSF dose of 10 μg/kg administration seems preferential to HD-CY plus a G-CSF dose of 5 μg/kg for PBSC collection because of equivalent or better efficiency in stem cell mobilization, strong favorable toxicity profile and reduced cost.Bone Marrow Transplantation (2006) 37, 725–729. doi:10.1038/sj.bmt.1705308; published online 6 March 2006
- Subjects
STEM cells; MULTIPLE myeloma; B cell lymphoma; GRANULOCYTE-colony stimulating factor; COLONY-stimulating factors (Physiology); LEUKAPHERESIS
- Publication
Bone Marrow Transplantation, 2006, Vol 37, Issue 8, p725
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705308