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- Title
Chemotherapy and donor leukocyte infusions for relapsed juvenile myelomonocytic leukemia (JMML).
- Authors
Neudorf, S.; Nourani, A.; Kempert, P.; Shen, V.; Sender, L.; Kirov, I.
- Abstract
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disease characterized by monocytosis, hepatosplenornegaly, elevated HbF levels, and is often associated with abnormalities in the NF-1 gene. JMML is fatal unless treated with allogeneic BMT. Donor leukocyte infusions (DLI) or withdrawal of immunosuppression have been reported to be an effective therapy for recurrent JMML, which suggests that JMML may benefit from a graft-versus-leukemia effect. Authors report a patient who relapsed following an unrelated donor BMT, who had a transient improvement in his JMML following DLI and ultimately required intensive chemotherapy and DLI to control his disease.
- Subjects
IMMUNOSUPPRESSION; MONOCYTIC leukemia; MYELOPROLIFERATIVE neoplasms; LEUKEMIA; IMMUNOREGULATION; DRUG therapy; GRAFT versus host disease
- Publication
Bone Marrow Transplantation, 2004, Vol 33, Issue 10, p1069
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704478