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- Title
Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer.
- Authors
Nishikawa, Jun; Iizasa, Hisashi; Yoshiyama, Hironori; Shimokuri, Kanami; Kobayashi, Yuki; Sasaki, Sho; Nakamura, Munetaka; Yanai, Hideo; Sakai, Kohei; Suehiro, Yutaka; Yamasaki, Takahiro; Sakaida, Isao
- Abstract
Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel therapeutic applications for EBVaGC.
- Subjects
DNA metabolism; ADENOCARCINOMA; APOPTOSIS; ENZYME inhibitors; EPSTEIN-Barr virus; EPSTEIN-Barr virus diseases; METHYLATION; STOMACH tumors; EPIGENOMICS; DISEASE complications; PHARMACODYNAMICS
- Publication
Cancers, 2018, Vol 10, Issue 6, p167
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers10060167