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- Title
The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies.
- Authors
Craver, Brianna M.; El Alaoui, Kenza; Scherber, Robyn M.; Fleischman, Angela G.
- Abstract
Hematopoietic stem cells (HSCs) maintain an organism’s immune system for a lifetime, and derangements in HSC proliferation and differentiation result in hematologic malignancies. Chronic inflammation plays a contributory if not causal role in HSC dysfunction. Inflammation induces HSC exhaustion, which promotes the emergence of mutant clones that may be resistant to an inflammatory microenvironment; this likely promotes the onset of a myeloid hematologic malignancy. Inflammatory cytokines are characteristically high in patients with myeloid malignancies and are linked to disease initiation, symptom burden, disease progression, and worsened prognostic survival. This review will cover our current understanding of the role of inflammation in the initiation, progression, and complications of myeloid hematologic malignancies, drawing from clinical studies as well as murine models. We will also highlight inflammation as a therapeutic target in hematologic malignancies.
- Subjects
CELL proliferation; BIOLOGICAL models; CELL differentiation; CYTOKINES; HEMATOPOIETIC stem cells; IMMUNE system; INFLAMMATION; INFLAMMATORY mediators; DISEASE progression; MYELOID leukemia; HEMATOLOGIC malignancies; DISEASE complications; LEUKEMIA treatment
- Publication
Cancers, 2018, Vol 10, Issue 4, p104
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers10040104