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- Title
The association of CHA<sub>2</sub>DS<sub>2</sub>-VASc score and carotid plaque in patients with non-valvular atrial fibrillation.
- Authors
Shang, Luxiang; Zhao, Yang; Shao, Mengjiao; Sun, Huaxin; Feng, Min; Li, Yaodong; Zhou, Xianhui; Tang, Baopeng
- Abstract
Objective: The aim of this study was to assess the association between CHA2DS2-VASc score and carotid plaques in patients with non-valvular atrial fibrillation (NVAF). Methods: We conducted a retrospective study including 3,435 NVAF patients who underwent carotid ultrasound examinations from January 2015 to December 2017.We collected the clinical data on the medical records system. Chi-square trend test was used to analyze trends between the prevalence of carotid plaques with an increasing CHA2DS2-VASc score. Univariate and multivariate logistic regression was also used to assess the association between carotid plaques and CHA2DS2-VASc scores. The area under the receiver operating characteristic (ROC) curve (AUC) was used to determine the optimal cutoff points of different CHA2DS2-VASc scores in NVAF patients. Results: NVAF patients with carotid plaques had higher CHA2DS2-VASc scores compared with patients who did not have carotid plaques (3.01±1.36 vs. 2.55±1.28, P < 0.05). In all participants, male participants and female participants, the prevalence of carotid plaques increased significantly as the CHA2DS2-VASc score increased (P for trend < 0.001). Multivariate logistic regression analysis demonstrated that for each 1-point increase in the CHA2DS2-VASc score, there was an associated 37% increase in the prevalence of carotid plaques. ROC curve analysis revealed that a CHA2DS2-VASc score ≥ 2 in male patients (sensitivity, 44.67%; specificity, 75.64%; AUC, 0.639) or ≥ 3 in female patients (sensitivity, 47.24%; specificity, 72.40%; AUC, 0.634) were associated with carotid plaques. Conclusion: The prevalence of carotid plaques in patients with NVAF was associated with the CHA2DS2-VASc score.
- Subjects
ATRIAL fibrillation; CAROTID artery stenosis; MEDICAL records; DISEASE prevalence; RECEIVER operating characteristic curves; ULTRASONIC imaging
- Publication
PLoS ONE, 2019, Vol 14, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0210945