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- Title
Variable Electrocardiographic Effects of Short-Term Quinidine Sulfate Administration in Brugada Syndrome.
- Authors
WATANABE, HIROSHI; CHINUSHI, MASAOMI; WASHIZUKA, TAKASHI; SUGIURA, HIROTAKA; HIRONO, TAKASHI; KOMURA, SATORU; HOSAKA, YUKIO; YAMAURA, MASAYUKI; TANABE, YASUTAKA; FURUSHIMA, HIROSHI; FUJITA, SATORU; AIZAWA, YOSHIFUSA
- Abstract
WATANABE, H.,et al.: Variable Electrocardiographic Effects of Short-Term Quinidine Sulfate Administration in Brugada Syndrome. Quinidine, a class I antiarrhythmic agent with blocking property of transient outward current, is a possible candidate for the suppression of ventricular fibrillation in patients with Brugada syndrome; although there is a concern that its ability to these effects may be proarrhythmic. Therefore, we evaluated the effect of quinidine sulfate on ST-segment elevation in Brugada syndrome. In 8 patients with Brugada syndrome, the magnitude of ST-elevation at the J-point (STJ), and the ST-segment configuration in leads V1–V3, were compared before and on day 2 after the initiation of quinidine administration. In 3 patients, quinidine attenuated STJ by≥0.1 mV. Of these 3 patients, ST-segment elevation was normalized in 2 patients, while the ST-segment configuration was unchanged in another. In another 3 patients, quinidine augmented STJ by≥0.1 mV without any change of ST-segment configuration, and the augmentation was returned to baseline after the discontinuation of quinidine. Quinidine exhibited no effect on the ST-segment in the remaining 2 patients. The favorable effects of quinidine on the ST-segment tended to be more pronounced in patients with prominent ST-elevation at baseline. In 1 patient, quinidine was effective in eliminating both ST-segment elevation and repetitive tachyarrhythmia episodes. In conclusion, the effects of quinidine on ST-segment elevation were variable. Quinidine may potentially augment the ST-segment elevation in some patients with Brugada syndrome.(PACE 2005; 28:372–377)
- Subjects
QUINIDINE; BRUGADA syndrome; SYNDROMES; VENTRICULAR fibrillation; TACHYARRHYTHMIAS
- Publication
Pacing & Clinical Electrophysiology, 2005, Vol 28, Issue 5, p372
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/j.1540-8159.2005.09494.x