We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Coronary Artery Disease Alters Ventricular Repolarization Dynamics in Type 2 Diabetes.
- Authors
VRTOVEC, BOJAN; SINKOVEC, MATJAZ; STARC, VITO; RADOVANCEVIC, BRANISLAV; SCHLEGEL, TODD T.
- Abstract
VRTOVEC, B.,et al.: Coronary Artery Disease Alters Ventricular Repolarization Dynamics in Type 2 Diabetes. Ventricular repolarization dynamics (VRD) is an important predictor of outcome in diabetes.We examined the potential impact of coronary artery disease (CAD) on VRD in type 2 diabetic patients. We recorded 5-minute high-resolution resting electrocardiograms in 38 diabetic patients undergoing elective coronary angiography, and in 38 age- and gender-matched apparently healthy subjects (controls). Using leads-I and -II, time-domain indices of VRD were calculated. Coronary angiography was regarded as positive if≥ 50% stenosis was found. Angiography was positive in 21 diabetic patients (55%). Patients with CAD had a significantly higher degree of VRD than controls (SDNN(QT): 15.81± 7.22 ms versus 8.94± 6.04 ms; P<0.001, rMSSD(QT): 21.02± 7.07 ms versus 11.18± 7.45 ms; P<0.001). Ventricular repolarization dynamics in diabetic patients with negative angiograms did not differ from VRD in controls (SDNN(QT): 8.94± 6.04 ms versus 7.44± 5.72 ms; P= 0.67, rMSSD(QT): 11.18± 7.45 ms versus 10.22± 5.35 ms; P= 0.82). CAD increases VRD in patients with type 2 diabetes. Therefore, changes in ventricular repolarization in diabetic patients may be due to silent CAD rather than due to diabetes per se.(PACE 2005; 28:S178–S181)
- Subjects
DIABETES; TYPE 2 diabetes; CORONARY disease; MORTALITY; PEOPLE with diabetes
- Publication
Pacing & Clinical Electrophysiology, 2005, Vol 28, pS178
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/j.1540-8159.2005.00076.x