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- Title
The evaluation of gene mutation profiles by next‐generation sequencing in diffuse large B‐cell lymphoma.
- Authors
Özçalımlı, Azime; Erdoğdu, İbrahim Halil; Turgutkaya, Atakan; Yavaşoğlu, İrfan; Döger, Füruzan Kaçar; Bolaman, Ali Zahit
- Abstract
Objective: Diffuse large B cell lymphoma (DLBCL) is the most common type of non‐Hodgkin lymphoma. Although it is a clinically and biologically heterogeneous disease, it is usually treated with R‐CHOP chemotherapy. Here, we aimed to investigate gene expression frequency with next‐generation sequencing (NGS) and the relation of gene mutations with remission and relapse status in patients with DLBCLs. Materials and Methods: We investigated gene mutation profiles by NGS in patients with DLBCL‐NOS and analyzed the correlation between gene mutations and response and relapse rates and other clinical indices. Results: Twenty‐eight of forty patients were evaluated. The most commonly mutated genes were ANKRD, BRCA1, BRCA2, EZH2, KMTC2, MYC, MYD88, NF1, NOTCH1, PMS2, PTEN, and WRN. The relapse rate was found higher in DLBCL patients with ANKRD26, BRCA2, MYD88, and NOTCH1 mutations. Also, remission duration was found shorter in patients with ANKRD26, BRCA2, and MYD88 mutations. Conclusions: Our study demonstrates that the presence of some genetic mutations is effective on prognosis in patients with DLBCL. NGS‐based evaluation of DLBCL treatment can be used in the future.
- Subjects
THERAPEUTIC use of antineoplastic agents; SEQUENCE analysis; GENETIC mutation; COMBINATION drug therapy; CANCER chemotherapy; B cell lymphoma; CANCER relapse; GENE expression profiling; DESCRIPTIVE statistics; DATA analysis software; NON-Hodgkin's lymphoma; DISEASE risk factors
- Publication
International Journal of Laboratory Hematology, 2023, Vol 45, Issue 3, p310
- ISSN
1751-5521
- Publication type
Article
- DOI
10.1111/ijlh.14012