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- Title
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1.
- Authors
F&ätkenheuer, Gerd; Pozniak, Anton L.; Johnson, Margaret A.; Plettenberg, Andreas; Staszewski, Schlomo; Hoepelman, Andy I. M.; Saag, Michael S.; Goebel, Frank D.; Rockstroh, Jürgen K.; Dezube, Bruce J.; Jenkins, Tim M.; Medhurst, Christine; Sullivan, John F.; Ridgway, Caroline; Abel, Samantha; James, Ian T.; Youle, Mike; van der Ryst, Elna
- Abstract
We assessed the efficacy and safety of 10-d monotherapy with the orally administered CCR5 antagonist maraviroc in 63 HIV-1-positive individuals prescreened for the absence of CXCR4-using virus. Maximum reduction in viral load occurred at a median of 10–15 d, with a mean reduction of ≥1.6 log10 copies/ml at all twice daily doses ≥100 mg. These results provide proof of concept that CCR5 antagonism is a viable antiretroviral therapeutic approach.
- Subjects
HIV-positive persons; ANTIRETROVIRAL agents; HIV; HTLV; HIV infections
- Publication
Nature Medicine, 2005, Vol 11, Issue 11, p1170
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1319