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- Title
Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).
- Authors
Tejpar, S; Li, C; Yu, C; Poon, R; Denys, H; Sciot, R; Cutsem, E Van; Cassiman, J J; Alman, B A
- Abstract
Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process.
- Subjects
FIBROMAS; T cells
- Publication
British Journal of Cancer, 2001, Vol 85, Issue 1, p98
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1054/bjoc.2001.1857