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- Title
Incidence of multiple primary cancers in a cohort of women diagnosed with breast cancer in southeast England.
- Authors
Evans, H S; Lewis, C M; Robinson, D; Bell, C M J; Møller, H; Hodgson, S V
- Abstract
Among women in the Thames Cancer Registry database with a first breast cancer diagnosed between 1961-1995 observed numbers of subsequent cancers were compared with expected numbers and standardized incidence ratios were calculated. The occurrence of breast cancers subsequent to cancers at other sites was also examined. Women diagnosed with breast cancer before age 50 had significantly elevated risks for 9 cancer sites namely, oesophagus, stomach, lung, bone, connective tissue, breast, corpus uteri, ovary and myeloid leukaemia compared with 2 sites (corpus uteri and myeloid leukaemia) in women diagnosed at age 50 and above. Some of these associations are consistent with the effects of known inherited cancer susceptibility genes, shared environmental factors, or therapy.
- Subjects
BREAST cancer; DISEASES in women
- Publication
British Journal of Cancer, 2001, Vol 84, Issue 3, p435
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1054/bjoc.2000.1603