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- Title
Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke.
- Authors
Giraud, Antoine; Dinomais, Mickaël; Garel, Pauline; Chevin, Mathilde; Thébault, Guillaume; Renaud, Cyrille; Presles, Émilie; Raia‐Barjat, Tiphaine; Sébire, Guillaume; Chabrier, Stéphane
- Abstract
Aim: To test the association between perinatal inflammation exposure and Full‐Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS). Method: We conducted a cross‐sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy‐three children were included (45 males, 28 females). The a priori defined primary outcome measure was the FSIQ score assessed with the Wechsler Intelligence Scale for Children, Fourth Edition at 7 years of age. Results: Seventeen (23%) of the included children were exposed to perinatal inflammation. Exposure to perinatal inflammation was independently associated with an increase of FSIQ score (coefficient 13.4, 95% confidence interval 1.3–25.4; p = 0.03). Children exposed to perinatal inflammation had a higher median cerebral volume, a lower median lesion volume, and less extensive lesion distributions compared to non‐exposed children. Interpretation: We propose the existence of two NAIS categories: arteritis‐associated NAIS in children exposed to perinatal inflammation and embolism‐associated NAIS in children non‐exposed to perinatal inflammation. Identifying these two NAIS categories would open the possibility for specific curative strategies: anti‐inflammatory strategy in arteritis‐associated NAIS and recanalization strategy in embolism‐associated NAIS.
- Subjects
ISCHEMIC stroke; WECHSLER Intelligence Scale for Children
- Publication
Developmental Medicine & Child Neurology, 2023, Vol 65, Issue 8, p1073
- ISSN
0012-1622
- Publication type
Article
- DOI
10.1111/dmcn.15522