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- Title
HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.
- Authors
Pääjärvi, Gerd; Roudier, Emilie; Högberg, Johan; Crisby, Milita; Stenius, Ulla
- Abstract
Discusses whether statins induce Akt activation in hepatocytes and whether this activation may induce changes in Mdm2/p53 regulation. Effect of statins on Mdm2/p53 regulation in unstressed and in DNA-damaged HepG2 cells; Effect of pravastatin on constitutive Mdm2 expression in rat liver in situ and on the p53 response to DNA damage; Phosphorylation of Mdm2 on Ser166.
- Subjects
STATINS (Cardiovascular agents); LIVER cells; DNA damage; PRAVASTATIN; PHOSPHORYLATION
- Publication
FASEB Journal, 2005, Vol 19, Issue 3, p476
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.04-2745fje