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- Title
Cost-effectiveness analysis of N95 respirators and medical masks to protect healthcare workers in China from respiratory infections.
- Authors
Mukerji, Shohini; MacIntyre, C. Raina; Seale, Holly; Quanyi Wang; Peng Yang; Xiaoli Wang; Newall, Anthony T.; Wang, Quanyi; Yang, Peng; Wang, Xiaoli
- Abstract
<bold>Background: </bold>There are substantial differences between the costs of medical masks and N95 respirators. Cost-effectiveness analysis is required to assist decision-makers evaluating alternative healthcare worker (HCW) mask/respirator strategies. This study aims to compare the cost-effectiveness of N95 respirators and medical masks for protecting HCWs in Beijing, China.<bold>Methods: </bold>We developed a cost-effectiveness analysis model utilising efficacy and resource use data from two cluster randomised clinical trials assessing various mask/respirator strategies conducted in HCWs in Level 2 and 3 Beijing hospitals for the 2008-09 and 2009-10 influenza seasons. The main outcome measure was the incremental cost-effectiveness ratio (ICER) per clinical respiratory illness (CRI) case prevented. We used a societal perspective which included intervention costs, the healthcare costs of CRI in HCWs and absenteeism costs.<bold>Results: </bold>The incremental cost to prevent a CRI case with continuous use of N95 respirators when compared to medical masks ranged from US $490-$1230 (approx. 3000-7600 RMB). One-way sensitivity analysis indicated that the CRI attack rate and intervention effectiveness had the greatest impact on cost-effectiveness.<bold>Conclusions: </bold>The determination of cost-effectiveness for mask/respirator strategies will depend on the willingness to pay to prevent a CRI case in a HCW, which will vary between countries. In the case of a highly pathogenic pandemic, respirator use in HCWs would likely be a cost-effective intervention.
- Subjects
CHINA; COST effectiveness; MECHANICAL ventilators; MASKS; COST analysis; RESPIRATORY disease prevention; MEDICAL personnel; SAFETY; INFLUENZA prevention; RESPIRATORY infections; INFLUENZA; BREATHING apparatus; CLINICAL trials; EPIDEMICS; STATISTICAL models; ECONOMICS; PREVENTION
- Publication
BMC Infectious Diseases, 2017, Vol 17, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-017-2564-9