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- Title
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
- Authors
Bailey, Leslie; Gylfe, Åsa; Sundin, Charlotta; Muschiol, Sandra; Elofsson, Mikael; Nordström, Peter; Henriques-Normark, Birgitta; Lugert, Raimond; Waldenström, Anders; Wolf-Watz, Hans; Bergström, Sven
- Abstract
Abstract: Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.
- Subjects
YERSINIA; CHLAMYDOPHILA pneumoniae; CHLAMYDIALES; HYDRAZONES
- Publication
FEBS Letters, 2007, Vol 581, Issue 4, p587
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.01.013