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- Title
Placental abnormalities detected by ultrasonography in a case of confined placental mosaicism for trisomy 2 with severe fetal growth restriction.
- Authors
Nagamatsu, Takeshi; Kamei, Yoshimasa; Yamashita, Takahiro; Fujii, Tomoyuki; Kozuma, Shiro
- Abstract
Clinical outcome of confined placental mosaicism ( CPM) is varied, from normal pregnancy to intrauterine fetal death. It has been suggested that CPM for trisomy 2 is less likely to cause serious adverse effect on pregnancy. We hereby report a case of CPM for trisomy 2, which presented severe fetal growth restriction ( FGR) and placental abnormalities. A 30-year-old woman was referred to our hospital at 17+2 weeks because of marked FGR. Ultrasonography demonstrated prominent placental hypertrophy with multiple focal defects without any fetal structural abnormalities. Amniocentesis at 18+3 weeks revealed normal karyotype. Fetal growth rate worsened with gestational weeks, reaching −7 standard deviation at 36 weeks. At 37 weeks, the fetal condition suddenly deteriorated, ending in a stillbirth of a 756-g female baby. Postnatal cytogenetic analysis by array comparative genomic hybridization revealed trisomy 2 of the chorionic villi, and CPM for trisomy 2 was suggested as the cause of FGR and placental abnormalities.
- Subjects
HUMAN abnormalities; FETAL growth retardation; EVALUATION of medical care; PLACENTA; PREGNANCY; SEX chromosome abnormalities; SEX differentiation disorders; ULTRASONIC imaging; DOWN syndrome; DISEASE complications
- Publication
Journal of Obstetrics & Gynaecology Research, 2014, Vol 40, Issue 1, p279
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.12145