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- Title
Pycnogenol<sup>®</sup> prevents haemolytic injury in G6PD deficient human erythrocytes.
- Authors
S. C. Sharma; S. Sharma; O. P. Gulati
- Abstract
Glucose6 phosphate dehydrogenase (G6PD) deficiency is the most common X-linked disorder of human erythrocytes where cells have inadequate capacity to destroy peroxides and high susceptibility towards haemolytic changes. Pycnogenol® is a proprietary dry extract of the French Maritime pine (Pinus pinaster) bark with high ability to scavenge free radicals. In the present study we have investigated if Pycnogenol® can protect G6PD deficient erythrocytes against haemolytic cell damage. Venous blood samples were obtained from six subject of Mediterranean origin with known G6PD deficiency which was also confirmed with standard techniques. Erythrocyte haemolysis in the presence and absence of Pycnogenol® was induced either with tert-butylhydroperoxide (t-BHP) or quinine and the haemoglobin release in the supernatant was determined by recording the optical density at 540 nm in a Shimadzu spectrophotometer. Our results have shown that Pycnogenol® has protective action against a Xenobiotic chemical induced haemolysis in G6PD deficient human erythrocytes. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects
GLUCOSE-6-phosphate dehydrogenase deficiency; HEMOLYTIC anemia; INBORN errors of metabolism; FRAGILE X syndrome; ERYTHROCYTES; PEROXIDES; CLUSTER pine
- Publication
Phytotherapy Research, 2003, Vol 17, Issue 6, p671
- ISSN
0951-418X
- Publication type
Article
- DOI
10.1002/ptr.1334