We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prognostic impact of HLA‐I neoantigen‐specific CD8+ T cells in limited‐stage follicular lymphoma.
- Authors
Tobin, J. W.; Tsang, H.; Patch, A.; Keane, C.; Law, S. C.; Gunawardana, J.; Blombery, P.; Thompson, E. R.; Sabdia, M. B.; De Long, L. M.; Nath, K.; Kazakoff, S. H.; Cheah, C.; Amanuel, B.; Cochrane, T.; Butler, J.; Johnston, A.; Shanavas, M.; Li, L.; Shelton, V.
- Abstract
Durable remissions occur in ~50% of LSFL patients whereas ASFL is incurable. In keeping with recent IHC CD8 protein data (Los-de Vries, Bld Adv 2022), CD8A gene expression was raised in stage I LSFL vs. 68 ASFL patients treated with immunochemotherapy ( I p i = 0.02). Recently, we demonstrated in limited and advanced stage FL (LSFL, ASFL), that patients with longer remissions had raised clonally expanded intratumoral CD8+ T cells (Tobin, JCO 2019).
- Subjects
FOLLICULAR lymphoma; T cells; CD8 antigen; COMBINED modality therapy
- Publication
Hematological Oncology, 2023, Vol 41, p276
- ISSN
0278-0232
- Publication type
Article
- DOI
10.1002/hon.3164_189