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- Title
Pharyngeal reflux episodes in patients with suspected laryngopharyngeal reflux versus healthy subjects: a prospective cohort study.
- Authors
Kim, Su Il; Jeong, Su Jin; Kwon, Oh Eun; Park, Jung Min; Doo, Jeon Gang; Park, Sang-In; Kim, Bo-Hyung; Lee, Young Chan; Eun, Young-Gyu; Ko, Seong-Gyu
- Abstract
Purpose: This study aimed to analyze pharyngeal reflux episodes in patients with suspected LPR versus healthy subjects using 24-h MII-pH monitoring. Methods: One hundred twenty-one patients who visited our clinic with a chief complaint of LPR-related symptoms and underwent 24-h MII-pH monitoring were enrolled prospectively. Also, 27 healthy subjects were enrolled and underwent 24-h MII-pH monitoring during the same period. We analyzed sensitivity, specificity, and accuracy comprehensively to determine appropriate cut-off values of pharyngeal reflux episodes in 24-h MII-pH monitoring to diagnose patients with LPR. Results: Twenty-nine of 121 patients with suspected LPR showed no pharyngeal reflux episodes, while 92 showed more than one pharyngeal reflux event. In contrast, the 22 healthy subjects showed no pharyngeal reflux episodes, three showed one reflux event, and two showed two reflux events. A cut-off value of ≥ 1 showed best accuracy reflected by combined sensitivity and specificity values, while ≥ 2 demonstrated better specificity with slight loss of sensitivity and slightly lower overall accuracy, suggesting cut-off value of ≥ 1 pharyngeal reflux episodes is a good clinical indicator. Conclusion: A cut-off value of ≥ 1 in pharyngeal reflux episodes on 24-h MII-pH monitoring in patients with suspected LPR might be an acceptable diagnostic tool for LPR.
- Subjects
SENSITIVITY &; specificity (Statistics); COHORT analysis; LONGITUDINAL method; PATIENT monitoring; SYMPTOMS
- Publication
European Archives of Oto-Rhino-Laryngology, 2021, Vol 278, Issue 9, p3387
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-021-06865-8