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- Title
The Impact of Antimicrobial Resistance in Cystic Fibrosis.
- Authors
Vitiello, Antonio; Blasi, Francesco; Sabbatucci, Michela; Zovi, Andrea; Miele, Francesco; Ponzo, Annarita; Langella, Roberto; Boccellino, Mariarosaria
- Abstract
The phenomenon of antimicrobial resistance (AMR) is a critical global health challenge, with prospects indicating its potential to become the leading cause of death worldwide in the coming years. Individuals with pre-existing conditions, such as neoplastic disease undergoing chemotherapy, those on immunosuppressive therapy, and individuals with rare diseases like cystic fibrosis (CF), face heightened challenges due to AMR. CF is a rare disease caused by a deficiency in the synthesis of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel protein, resulting in multi-organ clinical symptoms, particularly in the respiratory system. PwCF experience recurrent pulmonary exacerbations triggered by bacterial or viral infections, making them particularly vulnerable to the impact of AMR. This review delves into the complex relationship between AMR and climate dynamics, focusing on the unique challenges faced by individuals with CF. It discusses the methods employed to measure AMR, its global impact on antibiotic resistance, and the specific microbial communities present in the CF airway. The review also explores the intricacies of antimicrobial resistance within the context of cystic fibrosis, emphasizing the urgent need for research in this field.
- Subjects
CYSTIC fibrosis transmembrane conductance regulator; DRUG resistance in microorganisms; CYSTIC fibrosis; RESPIRATORY organs; DRUG resistance in bacteria
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 6, p1711
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13061711