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- Title
Fisiopatologia da doença renal crônica em adultos com doença falciforme.
- Authors
Lima, Larissa C.; Omena, Juliana; Lanziani, Renata; Citelli, Marta; Avesani, Carla Maria; dos S. Cople-Rodrigues, Claudia
- Abstract
Sickle cell disease (SCD) is the term used for genetic disorders characterized by the presence of hemoglobin S (HbS). Different genotypes are found in SCD patients and include sickle cell anemia (HbSS), the HbS associations with other variants of hemoglobin (HbD, HbC) and interactions with thalassemia. A major complication associated with SCD is sickle cell nephropathy. The objective of this study is to review the pathophysiology of chronic kidney disease (CKD) in adults with SCD. This is a simple review study, structured with articles published between 2005 and 2015, using the keywords "sickle cell disease", "chronic kidney disease" and "nephropathy" in PubMed / MEDLINE databases, using only studies in humans in the adult age. The vaso-occlusive phenomena and severe hemolysis cause tissue damage leading to organ damage, including kidneys. The various types of observed renal abnormalities, such as hyposthenuria, poor acidification of urine, hematuria, proteinuria, are frequent because the medullary portion of the kidney is an area particularly characterized by anoxia, hypertonicity and low pH, which are favorable conditions for sickling. Although the pathophysiology of sickle cell nephropathy occurs more markedly in individuals homozygous for hemoglobin S (HbSS), clinical manifestations of kidney disease are also observed in heterozygous individuals. The increasing prevalence of CKD is directly related to aging and impacts on the prognosis of SCD.The care of patients with SCD should be adopted since childhood, since the CKD and the SCD worsen with increasing age and the prognosis of SCD is even worse in the presence of CKD.
- Publication
Revista Hospital Universitário Pedro Ernesto (HUPE), 2015, Vol 14, Issue 3, p58
- ISSN
1983-2567
- Publication type
Article
- DOI
10.12957/rhupe.2015.19941