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- Title
Behavioral Intervention Improves Treatment Outcomes Among HIV-Infected Individuals Who Have Delayed, Declined, or Discontinued Antiretroviral Therapy: A Randomized Controlled Trial of a Novel Intervention.
- Authors
Gwadz, Marya; Cleland, Charles; Applegate, Elizabeth; Belkin, Mindy; Gandhi, Monica; Salomon, Nadim; Banfield, Angela; Leonard, Noelle; Riedel, Marion; Wolfe, Hannah; Pickens, Isaiah; Bolger, Kelly; Bowens, DeShannon; Perlman, David; Mildvan, Donna
- Abstract
Nationally up to 60 % of persons living with HIV are neither taking antiretroviral therapy (ART) nor well engaged in HIV care, mainly racial/ethnic minorities. This study examined a new culturally targeted multi-component intervention to address emotional, attitudinal, and social/structural barriers to ART initiation and HIV care. Participants (N = 95) were African American/Black and Latino adults with CD4 < 500 cells/mm not taking ART, randomized 1:1 to intervention or control arms, the latter receiving treatment as usual. Primary endpoints were adherence, evaluated via ART concentrations in hair samples, and HIV viral load suppression. The intervention was feasible and acceptable. Eight months post-baseline, intervention participants tended to be more likely to evidence 'good' (that is, 7 days/week) adherence (60 vs. 26.7 %; p = 0.087; OR = 3.95), and had lower viral load levels than controls (t(22) = 2.29, p = 0.032; OR = 5.20), both large effect sizes. This highly promising intervention merits further study.
- Subjects
ANTIRETROVIRAL agents; BEHAVIOR therapy; BLACK people; DRUGS; HEALTH services accessibility; HEALTH status indicators; HISPANIC Americans; HIV infections; PATIENT compliance; VIRAL load; RANDOMIZED controlled trials; MOTIVATIONAL interviewing; TREATMENT effectiveness; ODDS ratio
- Publication
AIDS & Behavior, 2015, Vol 19, Issue 10, p1801
- ISSN
1090-7165
- Publication type
Article
- DOI
10.1007/s10461-015-1054-6