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- Title
Chilblains outbreak during COVID‐19 pandemic: A Type‐I interferonopathy?
- Authors
Mensa‐Vilaró, Anna; Vicente, Asunción; Español‐Rego, Marta; Antón, Jordi; Fabregat, Virginia; Fortuny, Claudia; González, Europa Azucena; Fumadó, Victoria; González‐Roca, Eva; Jou, Cristina; Plaza, Susana; Mosquera, Juan Manuel; Yagüe, Jordi; Prat, Carolina; Pascal, Mariona; Juan, Manel; Arostegui, Juan I.; Baselga, Eulalia; Alsina, Laia
- Abstract
They showed type-I IFN polarization in COVID-toes patients compared with HC.13 We assessed whole blood type-I IFN signature based on the expression of 28 ISG (Table S7) in 24 patients, and we observed that 29.2% (7/24) of enrolled patients displayed increased ISG scores (Table S4 and Figure S1). Patients with COVID-toes evaluated before 7 days of onset of the skin lesions show statistical increase in 28-IRG score compared with patients who started later than 7 days. On the other hand, the strengths of our study are that we describe a relatively big and homogeneous cohort of young patients with COVID-toes, and to our knowledge, this is the first report that examines IFN signature in pediatric patients with COVID-toes.
- Subjects
COVID-19 pandemic; FOOT pain; MULTISYSTEM inflammatory syndrome in children; COVID-19
- Publication
Pediatric Allergy & Immunology, 2022, Vol 33, Issue 10, p1
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.13860