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- Title
Targeted Metabolomics to Assess Exposure to Environmental Chemicals of Concern in Japanese Quail at Two Life Stages.
- Authors
Legrand, Elena; Basu, Niladri; Hecker, Markus; Crump, Doug; Xia, Jianguo; Chandramouli, Bharat; Butler, Heather; Head, Jessica A.
- Abstract
This proof-of-concept study characterizes the Japanese quail (Coturnix japonica) hepatic metabolome following exposure to benzo[a]pyrene, chlorpyrifos, ethinylestradiol, fluoxetine hydrochloride, hexabromocyclododecane, lead(II)nitrate, seleno-L-methionine, and trenbolone in embryos and adults. The analysis revealed effects on lipid metabolism following exposure to several chemicals at both life stages. The most pronounced effects were observed in embryos exposed to 41.1 μg/g chlorpyrifos. This work highlighted challenges and the need for further avian metabolomics studies.
- Subjects
ENVIRONMENTAL exposure; JAPANESE quail; METABOLOMICS; CHLORPYRIFOS; ETHINYL estradiol; LIPID metabolism; HEXABROMOCYCLODODECANE
- Publication
Metabolites (2218-1989), 2021, Vol 11, Issue 12, p850
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo11120850