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- Title
Involvement of M1/M2 Macrophage Polarization in Reparative Dentin Formation.
- Authors
Kadowaki, Masataka; Yoshida, Shinichiro; Itoyama, Tomohiro; Tomokiyo, Atsushi; Hamano, Sayuri; Hasegawa, Daigaku; Sugii, Hideki; Kaneko, Hiroshi; Sugiura, Risa; Maeda, Hidefumi
- Abstract
Therefore, this study aimed to investigate the emergence of macrophages in dental pulp tissue after direct pulp capping, and the effect of M2 macrophages on the odontoblastic differentiation of DPSC clones. In the present study, the number of M1 macrophages increased at the pulp exposure site soon after injury, followed by an increase in the M2 macrophages as M1 macrophages disappeared and the reparative dentin formation started. Keywords: macrophage; direct pulp capping; dental pulp stem cell; reparative dentin formation; odontoblastic differentiation EN macrophage direct pulp capping dental pulp stem cell reparative dentin formation odontoblastic differentiation 1812 11 11/17/22 20221101 NES 221101 1. In the present study, M1 macrophages increased soon after the dental pulp exposure and decreased as the M2 macrophages started to emerge, indicating an inflammatory response at the early phase of the wound healing by the M1 macrophages and their proper polarization to the M2 macrophages.
- Subjects
MACROPHAGES; DENTIN; TRANSFORMING growth factors-beta; TUMOR necrosis factors
- Publication
Life (2075-1729), 2022, Vol 12, Issue 11, p1812
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life12111812