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- Title
Combined intra-tendinous injection of Platelet Rich Plasma and bevacizumab accelerates and improves healing compared to Platelet Rich Plasma in tendinosis: comprehensive assessment on a rat model.
- Authors
Dallaudiere, Benjamin; Zurlinden, Olivier; Perozziello, Anne; Deschamps, Lydia; Larbi, Ahmed; Louedec, Liliane; Pesquer, Lionel; Benayoun, Yohan; Silvestre, Alain; Serfaty, Jean Michel
- Abstract
Purpose: the aim of our study was to assess the potential of combined intratendinous injection of an anti-angiogenic drug: bevacizumab (AA) and Platelet Rich Plasma (PRP) to treat tendinopathy in a murine model of patellar and Achilles tendinopathy, and to evaluate its local toxicity. Material and method: twenty rats (80 patellar and Achilles tendons) were used for the study. We induced tendinosis (T+) in 80 tendons (patellar=40 and Achilles=40) by injecting under ultrasonography (US) guidance Collagenase 1® (day 0 = D0). Clinical examination was performed at D3, immediately followed by either PRP and AA (AAPRPT+, n=40) or PRP (PRPT+ n=40, control) US-guided intratendinous injection. Follow-up at D6, D18 and D25 using clinical, US and histology, and comparison between the 2 groups were performed. To study AA+PRP toxicity, we looked for necrosis or rupture on the 40 AAPRPT+. Results: all AAPRPT+ showed better joint mobilization compared to PRPT+ at D6 (p=0.03), D18 (p=0.04) and D25 (p=0.02). Similar results were found regarding US and histology, with smaller collagen fiber diameters (D6, p⩽0.017, D25, p⩽0.015), less disorganization and fewer neovessels (D25, p=0.004) in AAPRPT+ compared to PRPT+. No AA+PRP local toxicity was discovered in histology assessment. Conclusion: our study suggests that combined injection of AA and PRP in tendinosis accelerates and improves tendon's healing compared PRP used alone, with no local toxicity.
- Subjects
COMBINATION drug therapy; ANIMAL experimentation; HISTOLOGICAL techniques; RATS; STATISTICS; TENDINITIS; DATA analysis; BEVACIZUMAB; DATA analysis software; DESCRIPTIVE statistics; PLATELET-rich plasma
- Publication
Muscles, Ligaments & Tendons Journal (MLTJ), 2014, Vol 4, Issue 3, p351
- ISSN
2240-4554
- Publication type
Article