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- Title
Association of long-term patterns of depressive symptoms and attention/executive function among older men with and without human immunodeficiency virus.
- Authors
Armstrong, Nicole; Surkan, Pamela; Treisman, Glenn; Sacktor, Ned; Irwin, Michael; Teplin, Linda; Stall, Ron; Martin, Eileen; Becker, James; Munro, Cynthia; Levine, Andrew; Jacobson, Lisa; Abraham, Alison
- Abstract
Older HIV-infected men are at higher risk for both depression and cognitive impairments, compared to HIV-uninfected men. We evaluated the association between longitudinal patterns of depressive symptoms and attention/executive function in HIV-infected and HIV-uninfected men aged 50+ years to understand whether HIV infection influenced the long-term effect of depression on attention/executive function. Responses to the Center for Epidemiologic Studies-Depression scale and attention/executive function tests (Trail Making Test Part B and Symbol Digit Modalities Test) were collected semiannually from May 1986 to April 2015 in 1611 men. Group-based trajectory models, stratified by HIV status, were used to identify latent patterns of depressive symptoms and attention/executive function across 12 years of follow-up. We identified three depression patterns for HIV-infected and HIV-uninfected men ( rare/never 50.0 vs. 60.6%, periodically depressed 29.6 vs. 24.5%, chronic high 20.5 vs.15.0%, respectively) and three patterns of attention/executive function for HIV-infected and HIV-uninfected men ( worst-performing 47.4 vs. 45.1%; average 41.9 vs. 47.0%; best-performing 10.7 vs. 8.0%, respectively). Multivariable logistic regression models were used to assess associations between depression patterns and worst-performing attention/executive function. Among HIV-uninfected men, those in the periodically depressed and chronic high depressed groups had higher odds of membership in the worst-performing attention/executive function group (adjusted odds ratio [AOR] = 1.45, 95% CI 1.04, 2.03; AOR = 2.25, 95% CI 1.49, 3.39, respectively). Among HIV-infected men, patterns of depression symptoms were not associated with patterns of attention/executive function. Results suggest that HIV-uninfected, but not HIV-infected, men with chronic high depression are more likely to experience a long-term pattern of attention/executive dysfunction.
- Subjects
HIV infection complications; MENTAL depression; EXECUTIVE function; SYMPTOMS; OLDER men; DISEASES in older people
- Publication
Journal of NeuroVirology, 2017, Vol 23, Issue 4, p558
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1007/s13365-017-0527-y