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- Title
Designing Vaccines to Neutralize Effective Toxin Delivery by Enterotoxigenic Escherichia coli.
- Authors
Fleckenstein, James M.; Sheikh, Alaullah
- Abstract
Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens.
- Subjects
ESCHERICHIA coli; VACCINES; MICROBIAL virulence; DIARRHEA; THERAPEUTICS; PATHOGENIC microorganisms; DEVELOPING countries
- Publication
Toxins, 2014, Vol 6, Issue 6, p1799
- ISSN
2072-6651
- Publication type
Article
- DOI
10.3390/toxins6061799