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- Title
The Tumor-Associated Macrophage-M2-Cancer Cell Complex and the Observation of Heterogeneous Modification of the Morphological Structure of Lung Adenocarcinoma.
- Authors
Xiao, Wei-Hua; Yao, Li-Ping; Li, Min; Wang, Min; Wu, Liang; Jiang, Mao-Fen; Ma, Hai-Fen; Li, Jun-Qiang; Chen, Guo-Rong
- Abstract
aim of this study was to investigate the effect of the tumor-associated macrophage-m2-cancer cell complex (TAM-M2-CC) on the heterostructural modification of lung adenocarcinoma. Methods: The expression of CD163+/CD68+ in macrophages in the microenvironment of 161 cases of lung adenocarcinoma was identified by dual immunohistochemistry, and the association between a TAM-M2-CC and its growth, as well as the histological changes in lung adenocarcinoma cells, was assessed. Results: The morphological change of lung adenocarcinoma was related to the number of m2 phenotypes of the macrophages in the microenvironment of lung adenocarcinoma. TAM-M2-CCs were involved in the process of cancer cell recognition, association, and reconstruction. Conclusion: The microenvironment of lung adenocarcinoma can affect the phenotypic distinction of macrophages, and the polarization recruitment, zombification, and formation of a TAM-M2-CC, which can also affect the local differentiation of lung adenocarcinoma to a certain extent. The applicable pathogenesis needs to be verified and studied further.
- Subjects
CELLULAR recognition; ADENOCARCINOMA; LUNGS; CANCER cells; IMMUNOHISTOCHEMISTRY
- Publication
OncoTargets & Therapy, 2020, Vol 13, p11139
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S267157