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- Title
Fungal keratitis caused by Pseudallescheria boydii: clinical and mycological characteristics.
- Authors
Izadi, Alireza; Soleimani, Mohammad; dos Santos, Claudy Oliveira; Tehupeiory-Kooreman, Marlou C.; Daie Ghazvini, Roshanak; Hashemi, Seyed Jamal; Gramishoar, Mohssen; Aminizadeh, Mehdi; Abedinifar, Zohre; Verweij, Paul E.; Khodavaisy, Sadegh
- Abstract
Background: Pseudallescheria keratitis is rare but important type of fungal keratitis because of the inherently resistance of the organism to many existing antifungal agents. Methods: Slit-lamp and confocal microscopy were used for clinical examinations. Fungal isolates were identified based on morphological characteristics and DNA sequence of the internal transcribed spacer region (ITS). In vitro antifungal susceptibility testing for fungal isolates was performed according to the Clinical and Laboratory Standards Institute (CLSI, M38-A2). Result: All patients had a history of ocular trauma. In clinical examination hypopion were seen in three patients. The main antifungal medications were topical voriconazole. After treatment the visual acuity of all patients improved in 2–3 weeks. Conclusion: All four patients of Pseudallescheria keratitis had similar clinical features. Accurate and rapid identification of species should be helpful in treating p. boydii keratitis.
- Subjects
FUNGAL keratitis; DNA sequencing; ANTIFUNGAL agents; VISUAL acuity; NUCLEOTIDE sequence; FUNGAL growth; CANDIDA
- Publication
Journal of Ophthalmic Inflammation & Infection, 2021, Vol 11, Issue 1, p1
- ISSN
1869-5760
- Publication type
Article
- DOI
10.1186/s12348-021-00255-1