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- Title
Cutaneous T-cell lymphoma: diagnosing subtypes and the challenges.
- Authors
Hague, Christina; Farquharson, Nina; Menasce, Lia; Parry, Eileen; Cowan, Richard
- Abstract
Cutaneous T-cell lymphoma is a rare type of extranodal non-Hodgkin's lymphoma that primarily affects the skin. The uncertain pathogenesis and variable clinical presentation make the diagnosis and management of cutaneous T-cell lymphoma a challenge. Cutaneous T-cell lymphoma is a chronic, relapsing illness with treatment aimed at symptomatic relief and improving patient related quality of life. Early-stage cutaneous T-cell lymphoma typically follows an indolent course, often being mistaken for benign dermatological conditions which can lead to a diagnostic delay. Advanced stage cutaneous T-cell lymphoma has a poor prognosis with significant morbidity. Accurate diagnosis and early involvement of a specialist team is paramount to ensure correct management and improved patient outcomes. Promising advances are being made to develop novel agents which could improve prognosis and quality of life. This article provides an overview of the two main subtypes of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome. Clinical presentation, histopathological correlation and diagnostic challenges are reviewed alongside example case studies.
- Subjects
EVALUATION of medical care; TUMOR classification; CYTOCHEMISTRY; QUALITY of life; CUTANEOUS T-cell lymphoma; SYMPTOMS
- Publication
British Journal of Hospital Medicine (17508460), 2022, Vol 83, Issue 4, p1
- ISSN
1750-8460
- Publication type
Article
- DOI
10.12968/hmed.2021.0149