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- Title
Opportunities and challenges: interleukin-22 comprehensively regulates polycystic ovary syndrome from metabolic and immune aspects.
- Authors
Geng, Yuli; Liu, Zhuo; Hu, Runan; Ma, Wenwen; Wu, Xiao; Dong, Haoxu; Song, Kunkun; Xu, Xiaohu; Huang, Yanjing; Li, Fan; Song, Yufan; Zhang, Mingmin
- Abstract
Polycystic ovary syndrome (PCOS) is known as a prevalent but complicated gynecologic disease throughout the reproductive period. Typically, it is characterized by phenotypic manifestations of hyperandrogenism, polycystic ovary morphology, and persistent anovulation. For now, the therapeutic modality of PCOS is still a formidable challenge. Metabolic aberrations and immune challenge of chronic low-grade inflammatory state are significant in PCOS individuals. Recently, interleukin-22 (IL-22) has been shown to be therapeutically effective in immunological dysfunction and metabolic diseases, which suggests a role in the treatment of PCOS. In this review, we outline the potential mechanisms and limitations of IL-22 therapy in PCOS-related metabolic disorders including its regulation of insulin resistance, gut barrier, systemic inflammation, and hepatic steatosis to generate insights into developing novel strategies in clinical practice.
- Subjects
POLYCYSTIC ovary syndrome; INTERLEUKIN-22; INFLAMMATION; INSULIN regulation; INDUCED ovulation; FATTY liver
- Publication
Journal of Ovarian Research, 2023, Vol 16, Issue 1, p1
- ISSN
1757-2215
- Publication type
Article
- DOI
10.1186/s13048-023-01236-9