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- Title
Molecular diversity of SIV<sub>smm</sub>/PBj and a cognate variant, SIV<sub>smm</sub>/PGg.
- Authors
Novembre, Francis J.; Hirsch, Vanessa M.; McClure, Harold M.; Johnson, Philip R.
- Abstract
The molecular diversity of SIVsmm/PBj proviral genomes in tissues of an infected macaque was analyzed. Molecular clones derived directly from intestinal tissue DNA were heterogenous, and contained LTRs with one or two NF‐kB binding sites. LTRs with one NF‐kB site predominated (~75%). Virions derived from biologically active chimeric DNA clones with one or two NF‐kB sites did not induce the acute death syndrome characteristic of PBj infection. These results suggest that either the duplicated NF‐kB site acts in concert with other important viral determinants, or plays no role in producing the PBj syndrome.
- Publication
Journal of Medical Primatology, 1991, Vol 20, Issue 4, p188
- ISSN
0047-2565
- Publication type
Article
- DOI
10.1111/j.1600-0684.1991.tb00517.x