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- Title
Individual exercise sessions alter circulating hormones and cytokines in HIV-infected men.
- Authors
Dudgeon, Wesley David; Phillips, Kenneth Doyle; Durstine, John Larry; Burgess, Stephanie E.; Lyerly, George William; Davis, John Mark; Hand, Gregory Allen
- Abstract
Exercise has the potential to impact disease by altering circulating anabolic and catabolic factors. It was the goal of this study to determine how different regimens of low-intensity and moderate-intensity exercise affected circulating levels of these anabolic and catabolic factors in HIV-infected men. Exercise-naive, HIV-infected men, medically cleared for study participation, were randomized into one of the following groups: a moderate-intensity group (MOD, who completed 30 min of moderate-intensity aerobic training followed by 30 min of moderate-intensity resistance training; a low-intensity group (LOW), who completed 60 min of treadmill walking; or a control group (CON), who attended the clinic but participated in no activity. Blood and saliva samples were collected at selected time points before, during, and after each of the 3 required sessions. Compared with baseline, the MOD group (n = 14) had a 135% increase in growth hormone (GH) (p < 0.05) and a 34% decrease in cortisol (CORT) (p < 0.05) at the post time point, a 31% increase in interleukin-6 (IL-6) (p < 0.05) at 30-min post exercise, and a 23% increase in IL-6 (p < 0.05) and a 13% decrease in soluble tumor necrosis factor receptor 2 (sTNFrII) (p < 0.05) at 60-min post exercise. The LOW (n = 11) group had a 3.5% decrease in sTNFrII (<0.05) at 30-min post exercise compared with baseline and a 49% decrease (p < 0.05) in GH at 60-min post exercise. The CON group (n = 13) had a decrease in GH at 30-min (62%, p < 0.05) and 60-min (61%, p < 0.05) post exercise compared with baseline. The increase in GH from baseline to post was greater in the MOD group (p < 0.05) and the decrease in CORT from pre to post was greater in the MOD group (p < 0.05) than in the other groups. These data suggest that individual sessions of both low-intensity and moderate-intensity exercise can alter circulating anabolic and catabolic factors in HIV-infected men. The changes in the MOD group present potential mechanisms for the increases in lean tissue mass seen with resistance exercise training.
- Subjects
SOUTH Carolina; ANTIVIRAL agents; AEROBIC exercises; AMERICAN Heart Association; ANALYSIS of variance; CELL receptors; CENTERS for Disease Control &; Prevention (U.S.); CLINICAL trials; CYTOKINES; DRUG use testing; EXERCISE; EXERCISE physiology; HIV infections; HORMONES; HYDROCORTISONE; INTERLEUKINS; MEN'S health; MUSCLE strength; MUSCLE strength testing; NURSING assessment; RESEARCH funding; SALIVA; STATISTICAL sampling; STATISTICS; TREADMILL exercise tests; TUMOR necrosis factors; DATA analysis; TREADMILLS; HUMAN growth hormone; PRE-tests &; post-tests; REPEATED measures design; AMERICAN College of Sports Medicine; EXERCISE intensity; BLOOD; ANALYTICAL chemistry; STANDARDS; DRUG therapy
- Publication
Applied Physiology, Nutrition & Metabolism, 2010, Vol 35, Issue 4, p560
- ISSN
1715-5312
- Publication type
Article
- DOI
10.1139/H10-045